Abhay Satoskar, M.D., Ph.D., Associate Professor
M.B.B.S., University of Bombay (India), 1989
M.D. - University of Bombay, India, 1992
University of Strathclyde, Glasgow, UK, 1996
Associate Professor, Microbiology and Molecular Virology,
Immunology, and Medical Genetics
Biology Graduate Studies Program
Biological Sciences Building
484W. 12 Ave.
Columbus, Ohio 43210
Phone: (614) 292 3243
Phone: (614) 292 2813
Area of Expertise
mechanisms that determine outcome of "New world" cutaneous and
Immunology of leishmaniasis.
laboratory is interested in understanding the immune mechanisms
that determine outcome of "New world" cutaneous and visceral
leishmaniasis caused by L. mexicana and L. donovani
respectively. We are particularly interested in studying the
role of cytokines in regulation of immune responses during these
two species of Leishmania and the use of cytokine and cytokine
receptor gene deficient mice has been a very powerful tool in
these studies. As cytokines can modulate functions of several
cells of the immune system in vivo , we are now using
cell-specific gene deficient mice lacking specific cytokine
receptors on specific immune cells such as macrophages and T
cells. These mice are generated using cre/lox technology that
enables us to delete a gene in cell-specific manner. We believe
that these studies will enable us to determine how cytokines
regulate immune responses in vivo during leishmaniasis. With
regards to L. donovani , our studies have focused on
understanding the regulation of effector cell responses in
murine visceral leishmaniasis caused by L. donovani . Of
particular interest to our group is the determining the immune
mechanisms that mediate protection and/or induce immunopathology
during VL. More recently, in collaboration with the McGill
University, we have initiated studies that focus on the
development of amastigote-specific single candidate vaccine
against visceral and "New world" cutaneous leishmaniasis that
cause considerable morbidity and mortality in humans. Another
area of research in our laboratory is understanding the
immunological basis of gender-related differences in
susceptibility to Leishmania. In these studies, we are
interested in determining the roles of sex-hormones in
modulation of immune response and determining the outcome of
Leishmania infection. Our long-term goal is to identify the
basic mechanisms by which cytokines regulate T cell responses
and host immunity to cutaneous leishmaniasis caused by L.
mexicana and visceral leishmaniasis caused by L. donovani and
utilize this knowledge to develop a vaccine against these
Wurster, AL., Rodgers, VL, Satoskar, AR., and
Grusby, MJ. IL-21 is a Th2 cytokine that specifically inhibits
IFN-gproduction during Th1 cell development. J. Exp. Med.
Pien, GC., Nguyen, KB., Malmgaard, L.,
Satoskar, AR, and Biron, CA. Innate cytokine functions in
promoting T cell responses to viral infections. J. Immunol.
Rodriguez-Sosa, R., Rosas, LE., Bojalil, R.,
David, JR, Satoskar, AR* and Terrazas, LI*. Migration inhibitory
factor plays a critical role in mediating protective immunity
against the extra-intestinal helminth parasite Taenia crassiceps.
(*Joint senior co-authors) Infect. and Immun. 2003; 71:1247-1254
Rodriguez-Sosa, M., Rosas, LE, Lu, B., Gerard,
C., and Satoskar, AR. Role of CC chemokine receptor 1 (CCR-1) in
regulation of immune response following cutaneous L. major
infection. Immunol and Cell Biol. 2003; 80:114-120.
Rodriguez-Sosa, M., Satoskar, AR, David, JR,
and Terrazas, LI. Altered T helper responses in CD40 and IL-12
deficient mice reveal a critical role for Th1 responses in
eliminating the helminth parasite Taenia crassiceps. Int. J.
Parasitol. 2003;33: 701-711.
Rosas, L., Durbin, J., and Satoskar, AR.
Development of protective immunity against cutaneous
leishmaniasis is dependent on STAT1-mediated IFN-signaling
pathway. Europ. J. Immunol. 2003;33: 1799-1805.