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The Ohio State University College of Dentistry  
    

John Sheridan, Ph.D., Professor

Education

Undergraduate:

  BS - Fordham University, 1972

Graduate:

  MS - Rutgers University, 1974

  Ph.D. - Rutgers University, 1976

Post Doctoral Training:

  Duke University

Appointments

Professor, Division of Oral Biology

The George C. Paffenbarger Alumni-Endowed Chair in Dental Research

Professor, Department of Molecular Virology, Immunology, and Medical Genetics

Faculty, Oral Biology Graduate Program

Faculty, Neuroscience Graduate Studies Program

Associate Dean for Research

Associate Director, Institute for Behavioral Medicine Research

Contact Information

Office Address:

3143 Postle Hall

305 W. 12th Ave

Columbus, OH 43210

 

Office Phone: (614) 688 4629

Lab Phone: (614) 292 2012

Fax: (614) 247 6945

Email: sheridan.1@osu.edu

Affiliations & Memberships

Member, American Association for the Advancement of Science (AAAS)

Member, American Association of Immunologists (AAI)

Member, American Society for Microbiology (ASM)

Member, American Society for Virology (ASV)

Member, American Association for Dental Research (AADR)

Member, Society for Experimental Biology and Medicine (SEBM)

Member, Society for Leukocyte Biology (SLB)

 

Area of Expertise

Viral Immunology, Neuroendocrine Immunology and Wound Healing

Teaching

 

 

Research Interests

  • Stress and Immune Response

  • Neuroendocrine Regulation of Viral Immunity

Research Summary

Research in my lab is directed towards understanding the pathways by which information from the central nervous system is transmitted to the periphery and affects physiological responses. Studies in the laboratory have defined a number of cellular and molecular mechanisms by which environmental factors, such as stress, affect the immune response. Recently, using a model of social stress, my lab has shown that exposure to repeated defeat, induces glucocorticoid resistance. Myeloid cells in the spleen and liver of socially-stressed, subordinate animals become insensitive to regulation by glucocorticoid hormones. These studies have demonstrated the importance of the hypothalamic-pituitary-adrenal axis and sympathetic nervous system on innate and adaptive immune responses. This research has been supported by the NIH (NIDCR, NIMH, NIA, NHBLI, and NIAID), and the John D. and Catherine T. MacArthur Foundation.
 

Publications

Avitsur R, Kavelaars A, Heijnen C, Sheridan J.F. Social stress and the regulation of tumor necrosis factor-alpha secretion. Brain, Behavior Immunity 19:311-317, 2005.

Engler, H., Bailey, M.T., Engler, A., Stiner, L., Quan, N., Sheridan, J.F. Interleukin-1 receptor type 1-deficient mice fail to develop social stress-associated glucocorticoid resistance in the spleen. Psychoneuroendocrinology 33:108-117, 2008.

Bailey, M.T. Engler, H., Powell, N.D., Padgett, D.A., and J. F. Sheridan Repeated social defeat increases bactericidal activity of splenic macrophages through a Toll-like receptor-dependent pathway. American Journal of Physiology; Regulatory, Integrative, and Comparative Physiology 293: R1180-1190, 2007.

Bonneau RH, Padgett DA, Sheridan JF. Twenty years of psychoneuroimmunology and viral infections in Brain, Behavior and Kinsey SG, Bailey MT, Sheridan JF, Padgett DA, Avitsur R. Repeated social defeat causes increased anxiety-like behavior and alters splenocyte function in C57BL/6 and CD-1 mice. Brain Behav Immun. 2007 May;21(4):458-66.

Kinsey, S. G., Bailey, M. T., Sheridan, J. F., Padgett, D. A. The inflammatory response to social defeat is exaggerated in aged mice. Physiology and Behavior 93:623-636, 2007.

Bailey M.T., Engler H., Sheridan J.F. Stress induces the translocation of cutaneous and gastrointestinal microflora to secondary lymphoid organs of C57BL/6 mice. J Neuroimmunol. 171:29-37, 2006.

Head, C.C., Farrow, M.J., Sheridan, J.F., and Padgett, D.A. Androstenediol reduces the anti-inflammatory effects of restraint stress during wound healing. Brain Behav Immun. 20:590-596, 2006

Bailey M.T., Engler H., Sheridan J.F. Stress induces the translocation of cutaneous and gastrointestinal microflora to secondary lymphoid organs of C57BL/6 mice. J Neuroimmunol. 2006 Feb;171(1-2):29-37.

Avitsur R., Hunzeker J., Sheridan J.F. Role of early stress in the individual differences in host response to viral infection. Brain, Behavior and Immunity 20:339-348, 2006.

Tseng, R., Padgett, D.A., Dhabhar, F., Engler, H. and Sheridan, J.F. Stress-induced modulation of NK activity during influenza viral infection: role of glucocorticoids and opioids. Brain, Behavior and Immunity 19:153-164, 2005.

Engler, A., Roy, S., Sen, C., Padgett, D.A., and Sheridan, J.F. Restraint stress alters lung gene expression in an experimental influenza A viral infection. J. Neuroimmunology, 162:103-111, 2005.

Engler ,H., Engler, A., Bailey, M.T., J.F. Sheridan. Tissue-specific alterations in the glucocorticoid sensitivity of immune cells following repeated social defeat in mice. J. Neuroimmunology 163:110-119, 2005.

Avitsur R, Kavelaars A, Heijnen C, Sheridan J.F. Social stress and the regulation of tumor necrosis factor-alpha secretion. Brain, Behavior Immunity 19:311-317, 2005.Immunity. Brain Behav Immun. 2007 Mar;21(3):273-80.


 

Book Chapters