Assistant Professor of Periodontology
B.D.S. Annamali University 1987; M.D.S., Madras Dental College,
1991: Certificate: The Ohio State University, 2006 Ph.D. The Ohio
State University, 2005.
The bacterial community profile in periodontal health and disease;
host-bacterial interactions, clinical research
Description of Research
My research focuses on studying oral bacterial profiles associated
with periodontal health and disease using an integrated approach
combining clinical research, epidemiology, molecular microbiology
and bioinformatics. I am also interested in exploring the
interaction between a health-compatible or a pathogenic bacterial
colonization and the human host. Two major projects are currently
underway in the laboratory. The first involves the characterization
of subgingival microbial profiles of periodontally healthy smokers
and smokers with periodontitis. Smoking can cause changes in the
human host, including host-associated bacterial colonization
factors. Thus, it is possible that smokers have a unique microbial
profile that is different from non-smokers. This has proved to be
the case in other ecosystems in the body. Our previous studies have
shown that most of the subgingival bacteria are uncultivated, and
hence are not known or recognized as pathogens. Current studies are
directed towards identifying previously unknown and unsuspected
bacterial species associated with health and disease in smokers.
I am also studying the role of host genetics on oral bacterial
colonization. Current studies are directed towards understanding the
role of the host genotype on determining host-specific bacterial
DeAngelo SJ, Kumar PS, Beck FM, Tatakis DN, Leblebicioglu B.
Early soft tissue healing around one-stage dental implants: clinical
and microbiologic parameters. Journal of Periodontology 78:1878-1886, 2007.
Kumar PS, Leys EJ, Bryk JM, Martinez FJ, Moeschberger ML,
Griffen AL. Changes in periodontal health status are associated with
bacterial community shifts as assessed by quantitative 16S cloning
and sequencing. Journal of Clinical Microbiology 44:3665-3673,
Kumar PS, Griffen AL, Moeschberger ML, Leys EJ.
Identification of candidate periodontal pathogens and beneficial
species by quantitative 16S clonal analysis. Journal of Clinical
Microbiology 43: 3944-3955, 2005.