Angelo J. Mariotti
Professor of Periodontology
B.S. Grove City College, 1978; Ph.D. West Virginia University, 1982;
D.D.S., West Virginia University, 1986; Certificate: Virginia
Commonwealth University, 1988; Diplomate of the American Board of
Sex steroid hormone effects in the oral cavity; relationship between
the oral cavity and endocrine end organs; clinical research
Description of Research
My primary research interest is how the endocrine system affects the
oral cavity and how tissues within the oral cavity may effect target
tissues of endocrine hormones. The homeostasis of the periodontium
is a complex, multifactorial relationship that involves, at least in
part, the endocrine system. The assertion that hormone-sensitive
periodontal tissues exist relies on several salient observations,
including the retention and metabolic conversion of sex steroid
hormones as well as the presence of steroid hormone receptors in
periodontal tissues. These biological findings correlated with
clinical observations confirm an increased prevalence of gingival
diseases with fluctuating sex steroid hormone levels, even when oral
hygiene remained unchanged. Both human and animal models are used to
explore the relationship of sex steroid hormones to the oral cavity.
Mariotti A: Estrogen and extracellular matrix influences
human gingival fibroblast proliferation and protein production.
Journal of Periodontology, 76:1387 – 1393, 2005.
Mariotti A: Laboratory testing of patients for systemic
conditions in periodontal practice. Periodontology 2000, 34:84 –
Preshaw PM, Knutsen M, and Mariotti A: Experimental
gingivitis in women using oral contraceptives. Journal of Dental
Research, 80:2011 – 2015, 2001.