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The Ohio State University College of Dentistry  
    

Research

John D. Walters

Professor of Periodontology

A.B. (chemistry), The University of North Carolina at Chapel Hill, 1977; D.D.S., The University of North Carolina at Chapel Hill, 1981; M.Med.Sci. (oral biology), Harvard University, 1984
Certificate in Periodontology, Harvard School of Dental Medicine, 1984

Phone: 614-292-1169
Email: walters.2@osu.edu

Research interests
Inflammation, neutrophil chemotactic receptor polymorphisms and their association with periodontitis, mechanisms for enhancing chemotherapy against invasive bacterial pathogens, factors that influence the distribution of antimicrobial agents in periodontal tissues, and the effect of prophylactic antibiotics on the course of wound healing around newly-placed dental implants.

Description of Research
My laboratory explores the relationship between the single nucleotide polymorphisms in the human formylpeptide (chemotactic peptide) receptor gene, formylpeptide receptor expression defects, neutrophil chemotaxis defects and susceptibility to aggressive periodontitis in African-Americans. In addition, we study transport systems that allow cells in the periodontium to take up and accumulate antibiotics and non-steroidal anti-inflammatory agents. Lastly, we conduct studies to ascertain whether these transporters influence the periodontal distribution of antibiotics and enhance their effectiveness.

Recent Publications
Lai P-C, Walters JD. Azithromycin kills invasive Aggregatibacter actinomycetemcomitans in gingival epithelial cells. Antimicrobial Agents and Chemotherapy 57:1347-1351, 2013.

Jain N, Lai P-C, Walters JD. Effect of gingivitis on azithromycin concentrations in gingival crevicular fluid. Journal of Periodontology 83:1122-1128, 2012.

Iskandar I, Walters JD. Clarithromycin accumulation by phagocytes and its effects on killing of Aggregatibacter actinomycetemcomitans. Journal of Periodontology 82:497-504, 2011.

Ho W, Eubank T, Leblebicioglu B, Marsh C, Walters JD.  Azithromycin decreases crevicular fluid volume and mediator content. Journal of Dental Research 89:831-835, 2010.