John D. Walters
Professor of Periodontology
A.B. (chemistry), The University of North Carolina at Chapel Hill,
1977; D.D.S., The University of North Carolina at Chapel Hill, 1981;
M.Med.Sci. (oral biology), Harvard University, 1984
Certificate in Periodontology, Harvard School of Dental Medicine,
Inflammation, neutrophil chemotactic receptor polymorphisms and
their association with periodontitis, mechanisms for enhancing
chemotherapy against invasive bacterial pathogens, factors that
influence the distribution of antimicrobial agents in periodontal
tissues, and the effect of prophylactic antibiotics on the course of
wound healing around newly-placed dental implants.
Description of Research
My laboratory explores the relationship between the
single nucleotide polymorphisms in the human formylpeptide (chemotactic
peptide) receptor gene, formylpeptide receptor expression defects,
neutrophil chemotaxis defects and susceptibility to aggressive
periodontitis in African-Americans. In addition, we study transport
systems that allow cells in the periodontium to take up and
accumulate antibiotics and non-steroidal anti-inflammatory agents.
Lastly, we conduct studies to ascertain whether these transporters influence the
periodontal distribution of antibiotics and enhance their effectiveness.
Lai P-C, Walters JD. Azithromycin kills invasive
Aggregatibacter actinomycetemcomitans in gingival epithelial
cells. Antimicrobial Agents and Chemotherapy 57:1347-1351,
Jain N, Lai P-C, Walters JD. Effect of gingivitis on
azithromycin concentrations in gingival crevicular fluid. Journal of
Periodontology 83:1122-1128, 2012.
Iskandar I, Walters JD. Clarithromycin accumulation by
phagocytes and its effects on killing of Aggregatibacter
actinomycetemcomitans. Journal of Periodontology 82:497-504,
Ho W, Eubank
T, Leblebicioglu B, Marsh C, Walters JD. Azithromycin
decreases crevicular fluid volume and mediator content. Journal of
Dental Research 89:831-835, 2010.