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Distinguished Lecture Series
The Ohio State University College of Dentistry invites world-renowned
investigators in oral health research to share their knowledge and expertise
with our community through the Distinguished Lecture Series. The series
helps to ensure that our students, faculty, researchers, and scientists
remain on the cutting edge of dental research.
Below is a short description of each lecture and accompanying video.
Please note that Adobe Flash Player is
required to view the videos. You can download the player here:
http://get.adobe.com/flashplayer/
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Dennis Drayna, Ph.D.
Chief, Section on Systems Biology of Communication Disorders
Laboratory of Molecular Genetics; National Institutes of
Health - National Institutes on Deafness and Other
Communication Disorders
"Our Genes and Our Sense
of Taste."
Dr. Drayna’s lecture presents the results of his research on
the substantial differences in taste perception that exist
between individuals, with a focus on identifying genetic
variations that contribute to these differences. His studies
have revealed previously unrecognized aspects of human taste
perception that may facilitate the discovery of worldwide
patterns of genetic diversity which affect taste perception
and food choices.
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John B. Brunski, M.S., Ph.D.
Senior Research Engineer at Stanford University's School of
Medicine - Division of Plastic and Reconstructive Surgery.
"A Look at Mechanobiology
of the Bone-Dental Implant Interface: Macro, Micro, and
Molecular Views."
Dr. Brunski, who holds both a B.S. and a Ph.D. in Metallurgy
and Materials Science from the University of Pennsylvania,
and an M.S. in Materials Science and Engineering from
Stanford University, focuses his research on oral and
maxillofacial implants and the bone-implant interface.
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Charles F. Shuler, D.M.D,
Ph.D,
Dean of Dentistry at the
University of British Columbia
"When Oral Biology and
Clinical Dentistry Collide: Bisphosphonates and Osteonecrosis of the
Jaw.”
Dr. Shuler's presentation
focuses on
osteonecrosis of the jaw and its linkage to the use of
bisphosphonate medications.
View Dr. Shuler's lecture: |
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Stephen Hecht,
Ph.D.
Wallin Land Grant Professor of
Cancer Prevention; American Cancer Society Research
Professor
"Mechanisms and Prevention of Tobacco-Induced Cancer"
October 23, 2009
Dr. Hecht's research focuses on understanding the mechanisms
by which carcinogens in tobacco products, the human diet,
and the general environment are metabolically activated and
detoxified in humans, with the aim of developing practical
strategies for cancer prevention.
View Dr. Hecht's lecture:
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David
Wong, D.M.D., D.M.
Sc.
Associate Dean of Research,
Director of Dental Research Institute, UCLA, Fellow
of American Association for the Advancement of Sciences
(AAAS), AADR Vice President
"Salivary
Diagnostics”
April 23, 2009
Salivary diagnostics play an important part in health
monitoring and disease detection. A number of foundational
research tools that use salivary diagnostics are now in
place with the recent development and maturation of two
diagnostic alphabets -- the salivary proteome and the
transcriptome. In addition, nanotechnology-based
biosensors are concurrently being developed to capture and
optimize multiplex disease-specific salivary bio markers for
disease detection. Using these foundational tools, the
translational application of salivary biomarkers for oral
cancer screening and detection has begun, resulting in the
discovery of a panel of salivary biomarkers of proteomic and
genomic origins that mark the presence of early stage oral
cancer with >90% clinical accuracy.
View Dr. Wong's lecture:
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Susan
Herring, Ph.D.
University of Washington
“We Are What We Eat: Jaw Muscles and the Skull”
February
17, 2009
The muscles of mastication are large and powerful. The pull
of these jaw muscles on their bony attachments constitutes
the largest load received by the skull outside of traumatic
impact. Masticatory muscle contraction is also the direct
cause of occlusal force and reaction loads on the
temporomandibular joint, or TMJ. Growth and maintenance of
bone (and probably cartilage) are responsive to mechanical
forces; therefore, changes in jaw muscle usage have
consequences for skull structure. The mechanical effect of
muscles on the skull is dynamic and complex, and thus far
has resisted accurate modeling. Techniques are available for
direct measurement in animal models, and exploration of the
relationships between masticatory muscle function and
craniofacial bones has shown an influence of muscle force on
condylar and sutural growth, and and even more striking
effect on bone density.
View Dr. Herring's lecture:
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Kenneth Hargreaves, D.D.S., Ph.D.
Chair,
Department of Endodontics, President’s Council Endowed Chair
in Research, University of Texas Health Science Center at
San Antonio
“Orofacial Pain Mechanisms”
January 23, 2008
Orofacial pan mechanisms are poorly understood, and pain
management strategies are less than effective. The families
of ion channels and transient receptor potential (TRP)
channels are likely candidates for detecting an array of
stimuli, including intense heat, cold, acids, and certain
noxious chemicals such as capsaicin or mustard oil. PRL (prolactin)
receptor antagonists may serve as a novel class of
analgesics; basic research into the role of TRP channels and
pain has resulted in the identification of several new
methods that may offer utility in the control of orofacial
pain.
Trigeminal Mechanisms of Pain - Feb 2007 |
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Robert
Burne, Ph.D.
Chair of Department of Oral Biology,
University of Florida
October 30, 2008,
Lecture 1: "Biofilms
and Caries: Sisyphus Meets Streptococcus Mutans"
Dr. Burne's first lecture focuses on Streptococcus mutans,
a bacterium commonly found in the mouth, and other organisms
that contribute to the initiation and progression of tooth
decay. This presentation also discusses molecular, genetic,
biochemical, ecological and clinical studies that ilustrate
dental caries; resistance of antagonistic interactions
between commensals and cariogenic organisms.
Lecture 2: “Complexities in Catabolite Modification of Gene Expression in
Streptococcus Mutans”
Dr. Burne's second lecture focuses on genetic and
biochemical studies which show that Streptococcus mutans
has developed a complex, hierarchical regulatory network
that includes diverse transcriptional regulators and
multpiple components of the sugar phosphotransferase system.
This hierarchical regulatory network also coordinates carbon
and energy metabolism in response to diverse environmental
and intercellular signals.
View Dr. Burne's lectures:
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Charles Turner, Ph.D.
Indiana University/Purdue
University
“Mechanobiology of Bone: Basic Principles and Clinical
Application”
February 20, 2008
Mechanobiology merges the older science of mechanics with
the newer and emerging disciplines of molecular biology and
genetics. At the center of mechanobiology is the cellular
process of mechanotransduction, or the way cells sense and
respond to mechanical forces, as well as the ways that
mechanical loads signal bone cells to build stronger bones.
A discussion of the methods for identifying the genes that
influence skeletal form and strength will also be included
in this presentation. |
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Antoni Tomsia, Ph.D.
Senior Scientist, Lawrence
Berkeley National Laboratory Materials Science Division
"Composites
and Scaffolds for Calcified Tissue Regeneration”
October 17, 2007
Permanent damage to organs and their constituent parts is a
major cause of morbidity in medicine. The development of a
systematic method to generate new organs would transform
medicine. Dr. Tomsia's presentation focuses on the design
and synthesis of artificial tooth-like and bone like
composites, as well as the development of novel strategies
for calcified tissue regeneration using natural materials
such as nacre, bone, or tooth as a guide through
architectural control that expands a range of scales from
the atomic to the macro levels. |
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Clifford Saper, M.D., Ph.D.
James Jackson
Putnam Professor of Neurology and Neuroscience, Chairman,
Department of Neurology, Harvard Medical School
“Hypothalamic Regulation of Sleep and Circadian
Rhythms”
April 19,
2007
Dr. Saper's lecture explores the circuitry of the brain that controls
basic functions such as wake-sleep cycles, brain responses
to immune stimulation, and the brain’s control of the
cardiovascular and respiratory systems.
Hypothalamic Regulation of Sleep and Circadian Rhythms - PowerPoint Presentation 30MB |
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Lawrence Tabak
NIDCR Director and NIH Roadmap
Research Teams of the Future Co-Chair
”The NIH Role in Catalyzing Team Research of the
Future"
October 26, 2006
Dentistry in the future will be different from that of today
because of advances in genomics that are enabling advances
in molecular medicine. Dentists of the future will play a
larger role in early diagnosis of disease than they do
today. This session also discusses the importance of
collaboration among and between disciplines, as well as the
involvement of industry groups in new investigations.
View Mr. Tabak's lecture:
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